Last update
5/23/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as ascorbic acid from ferment media)
30 mg
33%
Vitamin E (as d-alpha-tocopheryl acetate from ferment media)
7.5 mg
50%
Folate (as folic acid from ferment media)
1333 mcg DFE
333%
Vitamin B12 (as cyanocobalamin from ferment media)
30 mcg
1250%
Iron (as ferrous fumarate from ferment media)
9 mg
50%
Zinc (as zinc oxide from ferment media)
5 mg
45%
Stress and Energy Support Blend (from ferment media)Organic Schizandra (berry), Organic Maca (root), Organic Chamomile (flower)
93.7 mg
•
Digestive Support Blend (from ferment media)Organic Aloe (leaf), Organic Peppermint (leaf), Organic Coriander (seed), Organic Cardamom (fruit), Organic Artichoke (leaf)
75 mg
•
Ginger (rhizome)1.6 mg aqueous extract and 0.4 mg organic supercritical extract
2 mg
•
Organic Turmeric (rhizome)1.3 mg from ferment media and 0.4 mg supercritical extract
1.7 mg
•
Top Medical Research Studies
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
7.5
Health improvement noted
2 people found this helpful
I ordered it after reading the reviews. After taking it, my heartbeat calmed and my overall health improved.
Read More
9
Increased energy levels
1 people found this helpful
I was astonished by how quickly my package arrived—just three days! I’m very impressed with the exceptional service from iHerb. Thank you! The vitamins are fantastic; since I started taking them during my six months of pregnancy, I have felt more energetic. Previously, I was iron deficient, but my iron levels have now returned to normal.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Health improvement noted
2 people found this helpful
I ordered it after reading the reviews. After taking it, my heartbeat calmed and my overall health improved.
Read More
9
Increased energy levels
1 people found this helpful
I was astonished by how quickly my package arrived—just three days! I’m very impressed with the exceptional service from iHerb. Thank you! The vitamins are fantastic; since I started taking them during my six months of pregnancy, I have felt more energetic. Previously, I was iron deficient, but my iron levels have now returned to normal.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. 10.1016/j.ejphar.2024.177205
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. 10.1007/s00011-025-02019-2
- Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. 10.1016/j.nicl.2025.103748
